Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

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Science Immunology  08 Oct 2020:
Vol. 5, Issue 52, eabe0367
DOI: 10.1126/sciimmunol.abe0367

Article Information

vol. 5 no. 52

Published By: 
  • Received July 28, 2020
  • Accepted October 5, 2020
  • .

Author Information

  1. Anita S. Iyera,b,*,
  2. Forrest K. Jonesc,*,
  3. Ariana Nodoushania,*,
  4. Meagan Kellya,
  5. Margaret Beckera,
  6. Damien Slatera,
  7. Rachel Millsa,
  8. Erica Teng, Investigationa,
  9. Mohammad Kamruzzamana,
  10. Wilfredo F. Garcia-Beltrand,
  11. Michael Astudillod,
  12. Diane Yangd,
  13. Tyler E. Millerd,
  14. Elizabeth Olivera,
  15. Stephanie Fischingere,
  16. Caroline Atyeoe,
  17. A. John Iafrated,
  18. Stephen B. Calderwooda,b,f,
  19. Stephen A. Lauer, Methodology, Supervision, Validationc,
  20. Jingyou Yug,
  21. Zhenfeng Lig,
  22. Jared Feldmane,
  23. Blake M. Hausere,
  24. Timothy M. Caradonnae,
  25. John A. Brandad,
  26. Sarah E. Turbetta,b,d,
  27. Regina C. LaRocquea,b,
  28. Guillaume Mellona,
  29. Dan H. Barouche,g,
  30. Aaron G. Schmidte,f,
  31. Andrew S. Azmanc,
  32. Galit Altere,
  33. Edward T Ryana,b,h,
  34. Jason B. Harrisa,i,# and
  35. Richelle C. Charlesa,b,#,
  1. aDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  2. bDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
  3. cDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  4. dDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  5. eRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  6. fDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
  7. gCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  8. hDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  9. iDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
  1. Address correspondence to Richelle C. Charles, rcharles{at}
  • * contributed equally to this work.

  • # contributed equally to this work.


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