November 2020
Vol 5, Issue 53

About The Cover

Cover image expansion

ONLINE COVER Pneumonia Prophylaxis. This month’s cover depicts intramuscular administration of a vaccine to an elderly man. Lower respiratory virus infections, including influenza and SARS-CoV-2, are more likely to progress to severe pneumonia and a fatal outcome in senior citizens. There is an urgent need for vaccines that show comparable efficacy in seniors and younger individuals. Using a mouse influenza infection model, Goplen et al. found that aged mice sustained more fibrotic lung damage following influenza infection than young mice due to excessive accumulation of dysfunctional tissue-resident memory T cells. [CREDIT: FG TRADE/GETTY IMAGES]