ReviewT CELLS

T cell factor 1: A master regulator of the T cell response in disease

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Science Immunology  06 Nov 2020:
Vol. 5, Issue 53, eabb9726
DOI: 10.1126/sciimmunol.abb9726

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Abstract

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.

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