Research ArticleANTIVIRAL IMMUNITY

Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia

See allHide authors and affiliations

Science Immunology  06 Nov 2020:
Vol. 5, Issue 53, eabc4557
DOI: 10.1126/sciimmunol.abc4557

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Role reversal for aged T cells

Age-related changes to the adaptive immune system are associated with impaired host response and increased morbidity and mortality after respiratory virus infection. Goplen et al. used a murine model of influenza virus infection to compare the function of lung tissue–resident memory T (TRM) cells in young and aged mice. Although TRM cells typically promote robust antiviral immunity, aged mice displayed increased accumulation of dysfunctional influenza-specific TRM cells that provided less protection against heterologous infection compared with TRM cells from young mice and facilitated pathological lung fibrosis. These results provide insight into how age and prior infection may affect T cell–mediated immunity to respiratory viruses such as influenza and SARS-CoV-2 and how these factors contribute to chronic lung pathology after viral pneumonia in older individuals.

View Full Text

Stay Connected to Science Immunology