Research ArticleMUCOSAL IMMUNOLOGY

Cellular context of IL-33 expression dictates impact on anti-helminth immunity

See allHide authors and affiliations

Science Immunology  13 Nov 2020:
Vol. 5, Issue 53, eabc6259
DOI: 10.1126/sciimmunol.abc6259

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

IL-33 and roundworm clearance

Immune control of helminth infections is achieved via type 2 immune responses involving group 2 innate lymphoid cells (ILC2), with the cytokine interleukin-33 (IL-33) supporting the expansion and activation of ILC2. Hung et al. used a mouse model of Nippostrongylus brasiliensis infection to investigate the effects of selectively deleting the IL-33 gene in intestinal epithelial cells or CD11c+ dendritic cells (DCs). Epithelial cell IL-33 promoted clearance of infection by ILC2, but IL-33 from DCs instead impaired worm clearance by enhancing Treg function. IL-33 expression by DCs increased expression of the pore-forming protein perforin-2, which may provide a conduit on the plasma membrane for IL-33 to leave the cell. These findings provide new insights into the cellular mechanisms controlling extracellular release of IL-33.

View Full Text

Stay Connected to Science Immunology