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Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis

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Science Immunology  20 Nov 2020:
Vol. 5, Issue 53, eabc7191
DOI: 10.1126/sciimmunol.abc7191

Article Information

vol. 5 no. 53

PubMed: 
Published By: 
History: 
  • Received May 9, 2020
  • Accepted October 29, 2020
  • .

Author Information

  1. Anne-Katrin Pröbstel1,2,*,
  2. Xiaoyuan Zhou1,
  3. Ryan Baumann1,
  4. Sven Wischnewski3,
  5. Michael Kutza3,
  6. Olga L. Rojas4,
  7. Katrin Sellrie5,
  8. Antje Bischof1,
  9. Kicheol Kim1,
  10. Akshaya Ramesh1,
  11. Ravi Dandekar1,
  12. Ariele L. Greenfield1,
  13. Ryan D. Schubert1,
  14. Jordan E. Bisanz6,7,
  15. Stephanie Vistnes8,
  16. Khashayar Khaleghi4,
  17. James Landefeld1,
  18. Gina Kirkish1,
  19. Friederike Liesche-Starnecker9,
  20. Valeria Ramaglia3,
  21. Sneha Singh1,
  22. Edwina B. Tran1,
  23. Patrick Barba1,
  24. Kelsey Zorn1,
  25. Johanna Oechtering2,
  26. Karin Forsberg10,
  27. Lawrence R. Shiow8,11,,
  28. Roland G. Henry1,
  29. Jennifer Graves1,,
  30. Bruce A. C. Cree1,
  31. Stephen L. Hauser1,
  32. Jens Kuhle2,
  33. Jeffrey M. Gelfand1,
  34. Peter M. Andersen10,
  35. Jürgen Schlegel9,
  36. Peter J. Turnbaugh6,7,
  37. Peter H. Seeberger5,
  38. Jennifer L. Gommerman4,
  39. Michael R. Wilson1,
  40. Lucas Schirmer3,12 and
  41. Sergio E. Baranzini1,13,14,*
  1. 1Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Neurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience Basel, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital of Basel, University of Basel, 4031 Basel, Switzerland.
  3. 3Department of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
  4. 4Department of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.
  5. 5Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14776 Potsdam, Germany.
  6. 6Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
  7. 7Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
  8. 8Eli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  9. 9Department of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, 81675 Munich, Germany.
  10. 10Department of Clinical Science, Neurosciences, Umeå University, 90185 Umeå, Sweden.
  11. 11Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
  12. 12Interdisciplinary Center for Neurosciences, University of Heidelberg, 69117 Heidelberg, Germany.
  13. 13Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.
  14. 14Graduate Program in Bioinformatics, University of California, San Francisco, San Francisco, CA 94158, USA.
  1. *Corresponding author. Email: anne-katrin.proebstel{at}usb.ch (A.-K.P.); sergio.baranzini{at}ucsf.edu (S.E.B.)
  • Present address: Discovery Medicine, BioMarin Pharmaceuticals Inc., Novato, CA 94949, USA.

  • Present address: Department of Neurosciences, University of California, San Diego, San Diego, CA, USA.

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