Research ArticleDENDRITIC CELLS

Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL

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Science Immunology  13 Nov 2020:
Vol. 5, Issue 53, eabe0347
DOI: 10.1126/sciimmunol.abe0347

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Distinct dendritic cell responses

Dendritic cells (DCs) are critical for activating naïve T cells by presenting antigen and providing costimulation, processes that are enhanced by cytokine signals from the surrounding environment. Girard et al. used single-cell proteogenomics and flow cytometry to examine cell type–specific responses of human peripheral blood monocyte and DC subsets to type I interferon. IFN-β induced maturation of the recently identified CD1c+ CD5 DC3 subset, which was characterized by distinct expression of the costimulatory molecule GITRL, a TNF family ligand, and driven by NF-κB signaling. These results identify conserved and cell type–specific features of the type I interferon response of human mononuclear phagocyte subsets, including the molecular signals monocytes and DCs may leverage to instruct T cells.

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