PerspectiveCORONAVIRUS

The known unknowns of T cell immunity to COVID-19

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Science Immunology  18 Nov 2020:
Vol. 5, Issue 53, eabe8063
DOI: 10.1126/sciimmunol.abe8063

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  • RE: Further Known Unknowns About T Cell Immunity to COVID-19

    The detailed and incisive explanation of known unknowns about T cell immunity in acute and convalescent COVID-19 infection is informative and helpful for medical specialists and every member of society.

    Further known unknowns include:

    (1) Does T cell immunity to SARS-CoV-2 apply equally in acute and convalescent COVID-19 infection?

    (2) How do preexisting conditions and comorbidities affect T cell immunity?

    (3) What specific T cells might have a detrimental impact on the clinical outcome and contribute to long COVID (or long hauler) symptoms?

    (4) What is the role of T cell immunity in separating long hauler COVID-19 from reinfection?

    (5) How do T cells affect the likely duration between initial infection and reinfection?

    (6) What are the different effects of T cell in vaccines in increasing protection against the virus for individuals who have not been infected, purportedly recovered patients, long hauler COVID-19, and reinfection?

    (7) What are the different durations of T cell in vaccines in increasing protection against the virus for individuals who have not been infected, purportedly recovered patients, long hauler COVID-19, and reinfection?  

    (8) Is T cell immunity to COVID-19 affected by factors such as age, gender, socio-economic inequalities, race, ethnicity, and general health conditions?

    Competing Interests: None declared.

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