Contents
January 2021
Vol 6, Issue 55
Vol 6, Issue 55
Focus
- TRH cells, helpers making an impact in their local community
T resident helper cells (TRH), a T cell subset with follicular helper and resident memory properties, regulate B cell responses in nonlymphoid organs (see the related Research Articles by Swarnalekha et al. and Son et al.).
Research Articles
- Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
An early memory CD8+ T cell precursor with distinct genome maintenance capacity depends on inhibitory receptor signaling.
- PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
Blockade of the PD-1 coinhibitory pathway compromises immune control of Mycobacterium tuberculosis infection in rhesus macaques.
- T resident helper cells promote humoral responses in the lung
Analysis of CD4+ T cell heterogeneity in the lung uncovers a Bcl6-dependent subset that supports mucosal antibody production.
- Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses
Identification of a CD4+ helper T cell population providing in situ help to B and CD8+ T cells in the respiratory mucosa.
Editors' Choice
- Killing the buzz: NK cells in the aged brain
Senescent neuroblasts activate NK cells in the dentate gyrus of the aged brain, leading to neuronal destruction that impairs cognition.
About The Cover
ONLINE COVER Helpful Lung Liaisons. This month's cover is a confocal immunofluorescence micrograph of mouse lung tissue showing CD4+ T cells (magenta) tightly associated with B220+ B cells (cyan) in an inducible bronchus–associated lymphoid tissue (iBALT) structure present 31 days after influenza infection. Swarnalekha et al. identified a BCL6-dependent subset of CD4+ T cells located within the iBALT that supports mucosal antibody production. This T cell subset, designated as resident helper T cells (TRH), is also the subject of a companion paper by Son et al. and a Focus commentary by Schattgen and Thomas. [CREDIT: N. SWARNALEKHA ET AL./SCIENCE IMMUNOLOGY]
