January 2021
Vol 6, Issue 55

About The Cover

Cover image expansion

ONLINE COVER Helpful Lung Liaisons. This month's cover is a confocal immunofluorescence micrograph of mouse lung tissue showing CD4+ T cells (magenta) tightly associated with B220+ B cells (cyan) in an inducible bronchus–associated lymphoid tissue (iBALT) structure present 31 days after influenza infection. Swarnalekha et al. identified a BCL6-dependent subset of CD4+ T cells located within the iBALT that supports mucosal antibody production. This T cell subset, designated as resident helper T cells (TRH), is also the subject of a companion paper by Son et al. and a Focus commentary by Schattgen and Thomas. [CREDIT: N. SWARNALEKHA ET AL./SCIENCE IMMUNOLOGY]