Contents
January 2021
Vol 6, Issue 55
Vol 6, Issue 55
First Release: Research Article
- Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells
Fewer SARS-CoV-2-reactive memory CD8+ T cells with ‘exhaustion’ features are present in COVID-19 patients with severe vs. mild disease.
Focus
- TRH cells, helpers making an impact in their local community
T resident helper cells (TRH), a T cell subset with follicular helper and resident memory properties, regulate B cell responses in nonlymphoid organs (see the related Research Articles by Swarnalekha et al. and Son et al.).
Research Resource
- Antigen identification for HLA class I– and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells
Cytokine-capturing antigen-presenting cells allow screening of complex DNA libraries for CD8+ and CD4+ T cell–targeted epitopes.
Research Articles
- Contribution of resident and circulating precursors to tumor-infiltrating CD8+ T cell populations in lung cancer
CD8+ T cells in lung tumors differentiate through convergent pathways to an expanded and actively cycling terminal state.
- Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
An inflammatory CD45RO+ ILC2 population found in inflamed human nasal tissue is steroid resistant and linked to type 2 immunopathology.
- Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
Specific immune cell populations resist anti–IL-4Rα therapy in atopic dermatitis, indicative of “disease memory” in healed skin.
- Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
An early memory CD8+ T cell precursor with distinct genome maintenance capacity depends on inhibitory receptor signaling.
- PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
Blockade of the PD-1 coinhibitory pathway compromises immune control of Mycobacterium tuberculosis infection in rhesus macaques.
- T resident helper cells promote humoral responses in the lung
Analysis of CD4+ T cell heterogeneity in the lung uncovers a Bcl6-dependent subset that supports mucosal antibody production.
- Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses
Identification of a CD4+ helper T cell population providing in situ help to B and CD8+ T cells in the respiratory mucosa.
Editors' Choice
- Killing the buzz: NK cells in the aged brain
Senescent neuroblasts activate NK cells in the dentate gyrus of the aged brain, leading to neuronal destruction that impairs cognition.
About The Cover
ONLINE COVER Helpful Lung Liaisons. This month's cover is a confocal immunofluorescence micrograph of mouse lung tissue showing CD4+ T cells (magenta) tightly associated with B220+ B cells (cyan) in an inducible bronchus–associated lymphoid tissue (iBALT) structure present 31 days after influenza infection. Swarnalekha et al. identified a BCL6-dependent subset of CD4+ T cells located within the iBALT that supports mucosal antibody production. This T cell subset, designated as resident helper T cells (TRH), is also the subject of a companion paper by Son et al. and a Focus commentary by Schattgen and Thomas. [CREDIT: N. SWARNALEKHA ET AL./SCIENCE IMMUNOLOGY]
