Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

Young Min Son; In Su Cheon; Yue Wu; Chaofan Li; Zheng Wang; Xiaochen Gao; Yao Chen; Yoshimasa Takahashi; Yang-Xin Fu; Alexander L. Dent; Mark H. Kaplan; Justin J. Taylor; Weiguo Cui; Jie Sun

doi:10.1126/sciimmunol.abb6852

Research ArticleANTIVIRAL IMMUNITY

Tissue-resident CD4⁺ T helper cells assist the development of protective respiratory B and CD8⁺ T cell memory responses

View ORCID ProfileYoung Min Son¹,²,
In Su Cheon¹,²,
View ORCID ProfileYue Wu¹,²,
Chaofan Li¹,²,
View ORCID ProfileZheng Wang¹,²,
Xiaochen Gao¹,²,
Yao Chen³,
Yoshimasa Takahashi⁴,
View ORCID ProfileYang-Xin Fu⁵,
View ORCID ProfileAlexander L. Dent ⁶,
View ORCID ProfileMark H. Kaplan ⁶,
View ORCID ProfileJustin J. Taylor⁷,
Weiguo Cui³,⁸ and
View ORCID ProfileJie Sun ¹,²,*

¹Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
²Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
³Versiti Blood Research Institute, Milwaukee, WI 53213, USA.
⁴Department of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
⁵Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
⁶Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁷Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
⁸Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

↵*Corresponding author. Email: sun.jie{at}mayo.edu

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Science Immunology 08 Jan 2021:
Vol. 6, Issue 55, eabb6852
DOI: 10.1126/sciimmunol.abb6852

Young Min Son

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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ORCID record for Young Min Son

In Su Cheon

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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Yue Wu

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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ORCID record for Yue Wu

Chaofan Li

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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Zheng Wang

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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ORCID record for Zheng Wang

Xiaochen Gao

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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Yao Chen

3Versiti Blood Research Institute, Milwaukee, WI 53213, USA.

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Yoshimasa Takahashi

4Department of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.

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Yang-Xin Fu

5Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.

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Alexander L. Dent

6Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Mark H. Kaplan

6Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Justin J. Taylor

7Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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Weiguo Cui

3Versiti Blood Research Institute, Milwaukee, WI 53213, USA.

8Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Jie Sun

1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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ORCID record for Jie Sun
For correspondence: sun.jie@mayo.edu

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Tissue-resident CD4⁺ T helper cells assist the development of protective respiratory B and CD8⁺ T cell memory responses

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