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Tumor-infiltrating lymphocyte lessons
The presence of intratumoral CD8+ tumor-infiltrating lymphocytes (TILs) is associated with better outcomes for patients with non–small cell lung cancer (NSCLC). These TILs consist of multiple subpopulations, and Gueguen et al. use single-cell RNA and T cell receptor sequencing to examine the origins and functional organization of TILs in NSCLC. They identified two precursor CD8+ TIL subpopulations with memory-like gene signatures. One of these subpopulations is detected in peripheral blood, whereas the other population is detected in juxtatumor tissue. Both subsets differentiate through a similar transitional stage into terminal effector TILs, which appear to be actively cycling within the tumor. Together, these results better define the origins and differentiation of CD8+ TILs associated with NSCLC.
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