Research ArticleSKIN INFLAMMATION

Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

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Science Immunology  22 Jan 2021:
Vol. 6, Issue 55, eabe2749
DOI: 10.1126/sciimmunol.abe2749

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The constants of atopic dermatitis recurrence

Atopic dermatitis (AD) is an inflammatory disease characterized by itching and widespread eczema. Moderate to severe AD is commonly treated by IL-4Rα blockade with dupilumab, yet cessation of this antibody therapy leads to disease recurrence, with the long-term immunologic effects of this treatment remaining unclear. Using scRNA-seq and proteomics of skin suction blisters from patients with AD, Bangert et al. characterized the immunologic milieu in AD skin during long-term IL-4Rα blockade. They identified that dendritic cells and T cells maintained an inflammatory phenotype during long-term IL-4Rα blockade, suggesting that these populations might be central to disease recurrence by maintaining a “disease memory.” These data and this dataset may contribute to the design of therapies that help prevent AD recurrence.

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