Research ArticleT CELLS

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

See allHide authors and affiliations

Science Immunology  15 Jan 2021:
Vol. 6, Issue 55, eabe3702
DOI: 10.1126/sciimmunol.abe3702

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Potent memory T cell precursors

Generation of memory T cells is an essential part of protective immunity against pathogens after initial infection or vaccination. Johnnidis et al. identified a subset of self-renewing early memory CD8+ T cell precursors in mice characterized by expression of CD62L and TCF-1 that emerge after viral infection. During lymphocytic choriomeningitis virus infection, this relatively small subset displayed restrained effector differentiation, genome maintenance activity associated with resistance to DNA damage, and a dependence on PD-1 and LAG-3 inhibitory receptors for memory formation. These results provide insight into the identity and features of memory T cell precursors that arise during acute infection and may also have implications for improving T cell responses in settings of chronic infection and cancer.

View Full Text

Stay Connected to Science Immunology