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Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

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Science Immunology  15 Jan 2021:
Vol. 6, Issue 55, eabe3702
DOI: 10.1126/sciimmunol.abe3702

Article Information

vol. 6 no. 55

Published By: 
  • Received September 28, 2020
  • Accepted December 10, 2020
  • .

Author Information

  1. Jonathan B. Johnnidis1,2,3,*,
  2. Yuki Muroyama2,3,*,
  3. Shin Foong Ngiow2,3,4,
  4. Zeyu Chen2,3,
  5. Sasikanth Manne2,3,
  6. Zhangying Cai5,
  7. Shufei Song6,
  8. Jesse M. Platt7,8,
  9. Jason M. Schenkel9,10,
  10. Mohamed Abdel-Hakeem2,3,
  11. Jean-Christophe Beltra2,3,4,
  12. Allison R. Greenplate2,3,
  13. Mohammed-Alkhatim A. Ali2,3,
  14. Kito Nzingha2,3,
  15. Josephine R. Giles2,3,4,
  16. Christelle Harly11,12,13,
  17. John Attanasio3,
  18. Kristen E. Pauken14,15,
  19. Bertram Bengsch16,17,
  20. Michael A. Paley18,
  21. Vesselin T. Tomov3,19,
  22. Makoto Kurachi20,
  23. Dario A. A. Vignali21,22,23,
  24. Arlene H. Sharpe14,15,
  25. Steven L. Reiner24,
  26. Avinash Bhandoola11,
  27. F. Bradley Johnson6 and
  28. E. John Wherry2,3,4,
  1. 1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO 63110, USA.
  6. 6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  7. 7Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  8. 8Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  9. 9Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  10. 10David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  11. 11T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  12. 12Université de Nantes, INSERM, CNRS, CRCINA, Nantes, France.
  13. 13LabEx IGO ‘Immunotherapy, Graft, Oncology’, Nantes, France.
  14. 14Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  15. 15Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.
  16. 16Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Germany.
  17. 17Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
  18. 18Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.
  19. 19Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  20. 20Department of Molecular Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
  21. 21Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  22. 22Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh PA 15232, USA.
  23. 23Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
  24. 24Department of Microbiology and Immunology and Department of Pediatrics, Columbia University, New York, NY 10032, USA.
  1. Corresponding author. Email: wherry{at}
  • * These authors contributed equally to this work.


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