February 2021
Vol 6, Issue 56

About The Cover

Cover image expansion

ONLINE COVER Progenitor Potential. This month's cover shows granule-bearing mouse mast cells derived from a 14-day in vitro culture of E-cadherin–expressing progenitor cells isolated from bone marrow. Wanet et al. identified E-cadherin as an early GATA-2–regulated marker of basophil and mast cell progenitor cell populations that was maintained as these two hematopoietic lineages matured. A Focus commentary by Dahlin discusses where the pro-BMP and pre-BMP populations characterized by Wanet et al. fit within a landscape model of hematopoietic cell differentiation. [CREDIT: WANET ET AL./SCIENCE IMMUNOLOGY]