Contents
February 2021
Vol 6, Issue 56
Vol 6, Issue 56
Focus
- Cutting down the hematopoietic tree: E-cadherin reveals a landscape of differentiating basophils and mast cells
GATA-2–mediated E-cadherin expression marks early progenitors primed to the basophil and mast cell lineages in mouse hematopoiesis (see the related Research Article by Wanet et al.).
Research Articles
- Prolonged evolution of the human B cell response to SARS-CoV-2 infection
Longitudinal analysis of the human B cell response to SARS-CoV-2 infection reveals prolonged antibody evolution.
- Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19
Tissue-resident memory-like TH17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
- Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Mast cells in type 2 airway inflammation exhibit heterogeneous inflammation-associated phenotypes and proliferate in situ.
- Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction
Targeting antigen to erythrocytes in vivo leads to a state of dysfunction and exhaustion in antigen-specific T cells.
- Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
Human uterine NK cells continuously differentiate in response to the monthly regeneration of the endometrium and during pregnancy.
- Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation
Distinct myeloid cell microenvironments in LNs promote divergent T cell programming during type I inflammation.
- E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates
E-cadherin expression on mouse hematopoietic progenitors marks their commitment to the basophil and mast cell fates at an early stage.
- IL-17 controls central nervous system autoimmunity through the intestinal microbiome
IL-17 is a key safeguard of intestinal homeostasis, indirectly modulating the autoimmune response against CNS antigens.
Research Resources
- Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
- Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics
Integrated single-cell transcriptomic and BCR analyses reveal how antibody class switching influences human B cell fate and function.
Editors' Choice
- TregGF-β: Deletion of TGF-β in Tregs revisited
Treg-specific ablation of TGF-β clarifies the complicated role of Treg-derived TGF-β in immunosuppression in vivo.
- Basophils getting on your nerves? Itching for clarity on flares in atopic dermatitis
Flares of acute itch in the setting of atopic dermatitis may engage a novel neuroimmune axis that includes basophils, LTC4, and sensory neurons.
About The Cover
ONLINE COVER Progenitor Potential. This month's cover shows granule-bearing mouse mast cells derived from a 14-day in vitro culture of E-cadherin–expressing progenitor cells isolated from bone marrow. Wanet et al. identified E-cadherin as an early GATA-2–regulated marker of basophil and mast cell progenitor cell populations that was maintained as these two hematopoietic lineages matured. A Focus commentary by Dahlin discusses where the pro-BMP and pre-BMP populations characterized by Wanet et al. fit within a landscape model of hematopoietic cell differentiation. [CREDIT: WANET ET AL./SCIENCE IMMUNOLOGY]
