Research ArticleMYELOID CELL DIFFERENTIATION

E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

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Science Immunology  05 Feb 2021:
Vol. 6, Issue 56, eaba0178
DOI: 10.1126/sciimmunol.aba0178

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Basophil lineage commitment

Basophils and mast cells are innate myeloid cells involved in IgE-mediated immediate hypersensitivity reactions, but identification of committed progenitors for these cell types has been challenging. Wanet et al. used gene expression data from hematopoietic progenitors in mice to identify E-cadherin as a candidate marker associated with early basophil/mast cell progenitors and present on some cells on which the high-affinity IgE receptor (FcεRIα) was not yet detected. E-cadherin expression in these progenitors was directly regulated by the GATA-2 transcription factor. Combining E-cadherin and the mature basophil marker CD49b will offer a technique for selecting mature basophils for functional studies while leaving FcεRIα untouched. These studies provide further insights into how hematopoietic progenitors commit to differentiate into basophils or mast cells.

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