E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

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Science Immunology  05 Feb 2021:
Vol. 6, Issue 56, eaba0178
DOI: 10.1126/sciimmunol.aba0178

Article Information

vol. 6 no. 56

Published By: 
  • Received October 28, 2019
  • Revision received September 9, 2020
  • Accepted January 4, 2021
  • .

Author Information

  1. Anaïs Wanet1,
  2. Mahmoud A. Bassal1,2,
  3. Sweta B. Patel3,
  4. Francisco Marchi1,
  5. Samanta A. Mariani4,
  6. Nouraiz Ahmed5,
  7. Haoran Zhang1,
  8. Marta Borchiellini6,7,
  9. Sisi Chen1,
  10. Junyan Zhang1,
  11. Annalisa Di Ruscio7,8,9,
  12. Kensuke Miyake10,
  13. Mindy Tsai11,
  14. Anuya Paranjape11,
  15. Shin-Young Park12,
  16. Hajime Karasuyama10,
  17. Timm Schroeder5,
  18. Elaine Dzierzak4,
  19. Stephen J. Galli11,13,
  20. Daniel G. Tenen1,2,*, and
  21. Robert S. Welner3,*,
  1. 1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  2. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  3. 3Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA.
  4. 4Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
  5. 5Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
  6. 6University of Eastern Piedmont, Department of Health Sciences, Novara 28100, Italy.
  7. 7University of Eastern Piedmont, Department of Translational Medicine, Novara 28100, Italy.
  8. 8Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.
  9. 9Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  10. 10Inflammation, Infection, Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  11. 11Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  12. 12Transfusion Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  13. 13Department of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. *Corresponding author. Email: rwelner{at} (R.S.W.); csidgt{at} (D.G.T.)
  • These authors contributed equally to this work as co-last authors.


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