E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

Anaïs Wanet; Mahmoud A. Bassal; Sweta B. Patel; Francisco Marchi; Samanta A. Mariani; Nouraiz Ahmed; Haoran Zhang; Marta Borchiellini; Sisi Chen; Junyan Zhang; Annalisa Di Ruscio; Kensuke Miyake; Mindy Tsai; Anuya Paranjape; Shin-Young Park; Hajime Karasuyama; Timm Schroeder; Elaine Dzierzak; Stephen J. Galli; Daniel G. Tenen; Robert S. Welner

doi:10.1126/sciimmunol.aba0178

Research ArticleMYELOID CELL DIFFERENTIATION

E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

View ORCID ProfileAnaïs Wanet ¹,
View ORCID ProfileMahmoud A. Bassal¹,²,
View ORCID ProfileSweta B. Patel³,
View ORCID ProfileFrancisco Marchi¹,
Samanta A. Mariani⁴,
View ORCID ProfileNouraiz Ahmed⁵,
Haoran Zhang¹,
View ORCID ProfileMarta Borchiellini⁶,⁷,
Sisi Chen¹,
Junyan Zhang¹,
View ORCID ProfileAnnalisa Di Ruscio ⁷,⁸,⁹,
View ORCID ProfileKensuke Miyake¹⁰,
Mindy Tsai¹¹,
Anuya Paranjape¹¹,
View ORCID ProfileShin-Young Park¹²,
View ORCID ProfileHajime Karasuyama¹⁰,
View ORCID ProfileTimm Schroeder⁵,
Elaine Dzierzak⁴,
View ORCID ProfileStephen J. Galli ¹¹,¹³,
View ORCID ProfileDaniel G. Tenen ¹,²,*,† and
View ORCID ProfileRobert S. Welner ³,*,†

¹Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
²Cancer Science Institute of Singapore, National University of Singapore, Singapore.
³Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA.
⁴Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
⁵Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
⁶University of Eastern Piedmont, Department of Health Sciences, Novara 28100, Italy.
⁷University of Eastern Piedmont, Department of Translational Medicine, Novara 28100, Italy.
⁸Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.
⁹Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
¹⁰Inflammation, Infection, Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
¹¹Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
¹²Transfusion Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
¹³Department of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305, USA.

↵*Corresponding author. Email: rwelner{at}uab.edu (R.S.W.); csidgt{at}nus.edu.sg (D.G.T.)

↵† These authors contributed equally to this work as co-last authors.

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Science Immunology 05 Feb 2021:
Vol. 6, Issue 56, eaba0178
DOI: 10.1126/sciimmunol.aba0178

Anaïs Wanet

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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Mahmoud A. Bassal

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

2Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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Sweta B. Patel

3Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA.

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Francisco Marchi

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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Samanta A. Mariani

4Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

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Nouraiz Ahmed

5Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

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Haoran Zhang

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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Marta Borchiellini

6University of Eastern Piedmont, Department of Health Sciences, Novara 28100, Italy.

7University of Eastern Piedmont, Department of Translational Medicine, Novara 28100, Italy.

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Sisi Chen

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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Junyan Zhang

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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Annalisa Di Ruscio

7University of Eastern Piedmont, Department of Translational Medicine, Novara 28100, Italy.

8Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.

9Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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Kensuke Miyake

10Inflammation, Infection, Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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Mindy Tsai

11Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Anuya Paranjape

11Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Shin-Young Park

12Transfusion Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

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Hajime Karasuyama

10Inflammation, Infection, Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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Timm Schroeder

5Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

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Elaine Dzierzak

4Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

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Stephen J. Galli

11Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

13Department of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Daniel G. Tenen

1Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

2Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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For correspondence: rwelner@uab.edu csidgt@nus.edu.sg

Robert S. Welner

3Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA.

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For correspondence: rwelner@uab.edu csidgt@nus.edu.sg

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E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

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