Research ArticleINNATE IMMUNITY

Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation

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Science Immunology  12 Feb 2021:
Vol. 6, Issue 56, eabb9435
DOI: 10.1126/sciimmunol.abb9435

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Teamwork for T cells

The location and interaction of innate immune cells in lymph nodes (LNs) contributes to the induction of T cell responses, yet the exact cells that contribute are unclear. Using advanced imaging techniques to characterize the spatial arrangement of innate and adaptive immune cells during TLR agonist-induced inflammation, Leal et al. show that LN-resident dendritic cells (DCs) and inflammatory monocytes cooperate to induce T cell responses. LN-resident DCs migrate to the T cell zone (TZ) in a CCR7-dependent manner and present antigen to T cells. Circulating monocytes enter the LN via high endothelial venules and become spatially polarized in the TZ, consequently inducing distinct inflammatory microenvironments and effector T cell subsets. Thus, DCs and monocytes in the LN TZ work together to induce T cell responses.

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