Research ResourcesNEUROIMMUNOLOGY

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

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Science Immunology  19 Feb 2021:
Vol. 6, Issue 56, eabd6279
DOI: 10.1126/sciimmunol.abd6279

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Time lapse of reparative myeloid cells

Myeloid cells can contribute to inflammation-associated tissue damage to the brain after stroke but can also facilitate repair by clearing debris and promoting tissue remodeling. Askenase et al. examined the dynamics of human myeloid cell transcriptomes in patients with intracerebral hemorrhage using RNA sequencing of neutrophils and monocytes/macrophages collected longitudinally from peripheral blood and hematomas. The acute response was characterized by elevated expression of genes associated with glycolysis, hypoxia response, and prostaglandin E2 synthesis in hematoma myeloid cells, and patients with superior neurological recovery displayed sustained engagement of these pathways. This resource provides insight into temporal regulation of transcriptional states in human myeloid cells after brain injury, highlighting glucose metabolism and lipid synthesis pathways in the reprogramming that occurs during the early stages of repair.

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