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Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

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Science Immunology  19 Feb 2021:
Vol. 6, Issue 56, eabd6279
DOI: 10.1126/sciimmunol.abd6279

Article Information

vol. 6 no. 56

Published By: 
History: 
  • Received July 2, 2020
  • Accepted January 21, 2021
  • .

Author Information

  1. Michael H. Askenase1,2,*,
  2. Brittany A. Goods3,4,5,6,*,
  3. Hannah E. Beatty1,2,
  4. Arthur F. Steinschneider1,2,
  5. Sofia E. Velazquez1,2,
  6. Artem Osherov1,2,
  7. Margaret J. Landreneau1,2,
  8. Shaina L. Carroll3,4,5,6,
  9. Tho B. Tran1,2,
  10. Victor S. Avram1,2,
  11. Riley S. Drake3,4,5,6,
  12. G. James Gatter3,4,5,6,
  13. Jordan A. Massey1,2,
  14. Saravanan S. Karuppagounder7,8,
  15. Rajiv R. Ratan7,8,
  16. Charles C. Matouk9,
  17. Kevin N. Sheth9,
  18. Wendy C. Ziai10,11,
  19. Adrian R. Parry-Jones12,13,
  20. Issam A. Awad14,
  21. Mario Zuccarello15,
  22. Richard E. Thompson10,16,
  23. Jesse Dawson17,
  24. Daniel F. Hanley10,
  25. J. Christopher Love4,5,18,,,
  26. Alex K. Shalek3,4,5,6,,,
  27. Lauren H. Sansing1,2,19,,,
  28. MISTIE III Consortium§,
  29. ICHseq investigators§
  1. 1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
  2. 2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  3. 3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
  4. 4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  5. 5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  6. 6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  7. 7Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
  8. 8Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  9. 9Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
  10. 10Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
  11. 11Departments of Neurology, Neurosurgery, and Anesthesiology/Critical Care Medicine, Johns Hopkins, Baltimore, MD, USA.
  12. 12Division of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
  13. 13Manchester Centre for Clinical Neurosciences, Salford Royal National Health Service Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
  14. 14Neurovascular Surgery Program, Section of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
  15. 15Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  16. 16Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  17. 17Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  18. 18Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  19. 19Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, USA.
  1. Corresponding author. Email: lauren.sansing{at}yale.edu (L.H.S.); shalek{at}mit.edu (A.K.S.); clove{at}mit.edu (J.C.L.)
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

    • § Author lists for MISTIE III Consortium and ICHseq investigators can be found in the Supplementary Materials.

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