Research ResourcesNEUROIMMUNOLOGY
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
- View ORCID ProfileMichael H. Askenase1,2,*,
- Brittany A. Goods3,4,5,6,*,
- View ORCID ProfileHannah E. Beatty1,2,
- Arthur F. Steinschneider1,2,
- View ORCID ProfileSofia E. Velazquez1,2,
- View ORCID ProfileArtem Osherov1,2,
- View ORCID ProfileMargaret J. Landreneau1,2,
- View ORCID ProfileShaina L. Carroll3,4,5,6,
- View ORCID ProfileTho B. Tran1,2,
- View ORCID ProfileVictor S. Avram1,2,
- View ORCID ProfileRiley S. Drake3,4,5,6,
- View ORCID ProfileG. James Gatter3,4,5,6,
- View ORCID ProfileJordan A. Massey1,2,
- Saravanan S. Karuppagounder7,8,
- Rajiv R. Ratan7,8,
- Charles C. Matouk9,
- View ORCID ProfileKevin N. Sheth9,
- Wendy C. Ziai10,11,
- Adrian R. Parry-Jones12,13,
- Issam A. Awad14,
- View ORCID ProfileMario Zuccarello15,
- Richard E. Thompson10,16,
- View ORCID ProfileJesse Dawson17,
- View ORCID ProfileDaniel F. Hanley10,
- View ORCID ProfileJ. Christopher Love4,5,18,†,‡,
- View ORCID ProfileAlex K. Shalek3,4,5,6,†,‡,
- View ORCID ProfileLauren H. Sansing1,2,19,†,‡,
- MISTIE III Consortium§,
- ICHseq investigators§
- 1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
- 2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
- 3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
- 4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
- 5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
- 7Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
- 8Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
- 9Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
- 10Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
- 11Departments of Neurology, Neurosurgery, and Anesthesiology/Critical Care Medicine, Johns Hopkins, Baltimore, MD, USA.
- 12Division of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- 13Manchester Centre for Clinical Neurosciences, Salford Royal National Health Service Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
- 14Neurovascular Surgery Program, Section of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
- 15Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
- 16Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
- 17Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
- 18Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
- 19Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, USA.
- ↵‡Corresponding author. Email: lauren.sansing{at}yale.edu (L.H.S.); shalek{at}mit.edu (A.K.S.); clove{at}mit.edu (J.C.L.)
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Science Immunology 19 Feb 2021:
Vol. 6, Issue 56, eabd6279
DOI: 10.1126/sciimmunol.abd6279
Vol. 6, Issue 56, eabd6279
DOI: 10.1126/sciimmunol.abd6279
Michael H. Askenase
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Brittany A. Goods
3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Hannah E. Beatty
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Arthur F. Steinschneider
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Sofia E. Velazquez
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Artem Osherov
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Margaret J. Landreneau
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Shaina L. Carroll
3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Tho B. Tran
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Victor S. Avram
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Riley S. Drake
3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
G. James Gatter
3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Jordan A. Massey
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Saravanan S. Karuppagounder
7Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
8Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Rajiv R. Ratan
7Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY, USA.
8Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Charles C. Matouk
9Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Kevin N. Sheth
9Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Wendy C. Ziai
10Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
11Departments of Neurology, Neurosurgery, and Anesthesiology/Critical Care Medicine, Johns Hopkins, Baltimore, MD, USA.
Adrian R. Parry-Jones
12Division of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
13Manchester Centre for Clinical Neurosciences, Salford Royal National Health Service Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
Issam A. Awad
14Neurovascular Surgery Program, Section of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Mario Zuccarello
15Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Richard E. Thompson
10Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
16Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jesse Dawson
17Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Daniel F. Hanley
10Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.
J. Christopher Love
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
18Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
Alex K. Shalek
3Institute for Medical Engineering & Science (IMES) and Department of Chemistry, MIT, Cambridge, MA, USA.
4Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Lauren H. Sansing
1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
2Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
19Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, USA.
