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Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

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Science Immunology  12 Feb 2021:
Vol. 6, Issue 56, eabe6291
DOI: 10.1126/sciimmunol.abe6291

Article Information

vol. 6 no. 56

PubMed: 
Published By: 
History: 
  • Received September 3, 2020
  • Accepted January 14, 2021
  • .

Author Information

  1. Hamish W. King1,2,*,
  2. Nara Orban3,
  3. John C. Riches4,5,
  4. Andrew J. Clear4,
  5. Gary Warnes6,
  6. Sarah A. Teichmann2,7 and
  7. Louisa K. James1,*
  1. 1Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
  2. 2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  3. 3Barts Health Ear, Nose and Throat Service, Royal London Hospital, London E1 1BB, UK.
  4. 4Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  5. 5Francis Crick Institute, London NW1 1AT, UK.
  6. 6Flow Cytometry Core Facility, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
  7. 7Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0EH, UK.
  1. *Corresponding author. Email: h.king{at}qmul.ac.uk, drhamishking{at}gmail.com (H.W.K.); louisa.james{at}qmul.ac.uk (L.K.J.)

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