Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

Hamish W. King; Nara Orban; John C. Riches; Andrew J. Clear; Gary Warnes; Sarah A. Teichmann; Louisa K. James

doi:10.1126/sciimmunol.abe6291

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Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

View ORCID ProfileHamish W. King ¹,²,*,
Nara Orban³,
View ORCID ProfileJohn C. Riches ⁴,⁵,
View ORCID ProfileAndrew J. Clear⁴,
View ORCID ProfileGary Warnes⁶,
View ORCID ProfileSarah A. Teichmann ²,⁷ and
View ORCID ProfileLouisa K. James ¹,*

¹Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
²Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
³Barts Health Ear, Nose and Throat Service, Royal London Hospital, London E1 1BB, UK.
⁴Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
⁵Francis Crick Institute, London NW1 1AT, UK.
⁶Flow Cytometry Core Facility, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
⁷Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0EH, UK.

↵*Corresponding author. Email: h.king{at}qmul.ac.uk, drhamishking{at}gmail.com (H.W.K.); louisa.james{at}qmul.ac.uk (L.K.J.)

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Science Immunology 12 Feb 2021:
Vol. 6, Issue 56, eabe6291
DOI: 10.1126/sciimmunol.abe6291

Hamish W. King

1Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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ORCID record for Hamish W. King
For correspondence: h.king@qmul.ac.uk drhamishking@gmail.com louisa.james@qmul.ac.uk

Nara Orban

3Barts Health Ear, Nose and Throat Service, Royal London Hospital, London E1 1BB, UK.

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John C. Riches

4Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.

5Francis Crick Institute, London NW1 1AT, UK.

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Andrew J. Clear

4Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.

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Gary Warnes

6Flow Cytometry Core Facility, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

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Sarah A. Teichmann

2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

7Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0EH, UK.

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Louisa K. James

1Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

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ORCID record for Louisa K. James
For correspondence: h.king@qmul.ac.uk drhamishking@gmail.com louisa.james@qmul.ac.uk

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Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

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