Research ArticleMUCOSAL VACCINES

Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells

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Science Immunology  19 Mar 2021:
Vol. 6, Issue 57, eabd8003
DOI: 10.1126/sciimmunol.abd8003

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Chaperoned vaccine primes pulmonary TRMs

Lung-dwelling tissue-resident memory T cells (TRMs) protect the lower respiratory system after exposure to previously encountered viral pathogens. Using a previously established amphiphilic vaccine formulation that binds avidly to albumin, Rakhra et al. investigated whether coordinated delivery to the lung mucosa of peptide antigen adjuvanted with a CpG oligonucleotide improved the generation of vaccine antigen-specific CD8+ pulmonary TRMs in mice compared with subcutaneous delivery. Intratracheal vaccine administration of the amphiphilic vaccine resulted in a substantial increase in cytokine-producing CD8+ TRMs in the lung and enhanced T cell–mediated protection against both virus and tumor cell challenges. These findings lay the groundwork for further development of amphiphilic mucosal vaccines delivered via an aerosol for induction of robust TRM-based immunity to viruses that threaten the human respiratory health.

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