Research ArticleHIV

HLA-E–restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

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Science Immunology  25 Mar 2021:
Vol. 6, Issue 57, eabg1703
DOI: 10.1126/sciimmunol.abg1703

Article Information

vol. 6 no. 57

Published By: 
  • Received December 15, 2020
  • Accepted February 18, 2021
  • .

Author Information

  1. Hongbing Yang1,
  2. Margarida Rei2,
  3. Simon Brackenridge1,
  4. Elena Brenna1,
  5. Hong Sun1,3,4,
  6. Shaheed Abdulhaqq5,
  7. Michael K. P. Liu6,
  8. Weiwei Ma6,
  9. Prathiba Kurupati2,
  10. Xiaoning Xu6,
  11. Vincenzo Cerundolo2,
  12. Edward Jenkins2,
  13. Simon J. Davis2,
  14. Jonah B. Sacha5,
  15. Klaus Früh5,
  16. Louis J. Picker5,
  17. Persephone Borrow1,
  18. Geraldine M. Gillespie1 and
  19. Andrew J. McMichael1,*
  1. 1NDM Research Building, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK.
  2. 2MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, UK.
  3. 3Key Laboratory of AIDS Immunology, Department of Laboratory Medicine, First Affiliated Hospital of China Medical University, Shenyang, China.
  4. 4Chinese Academy of Medical Sciences Oxford Institute, NDM, Oxford University, Oxford, UK.
  5. 5Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
  6. 6Centre For Immunology and Vaccinology, Chelsea and Westminster Hospital, Imperial College, London, UK.
  1. *Corresponding author. Email: andrew.mcmichael{at}


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