Research ArticleCORONAVIRUS

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses

See allHide authors and affiliations

Science Immunology  04 Mar 2021:
Vol. 6, Issue 57, eabg6461
DOI: 10.1126/sciimmunol.abg6461

Article Information

vol. 6 no. 57

PubMed: 
Published By: 
History: 
  • Received January 19, 2021
  • Accepted February 27, 2021
  • .

Author Information

  1. Benedikt Agerer1,,
  2. Maximilian Koblischke2,,
  3. Venugopal Gudipati3,,
  4. Luis Fernando Montaño-Gutierrez4,
  5. Mark Smyth1,
  6. Alexandra Popa1,
  7. Jakob-Wendelin Genger1,
  8. Lukas Endler1,
  9. David M. Florian2,
  10. Vanessa Mühlgrabner3,
  11. Marianne Graninger2,
  12. Stephan W. Aberle2,
  13. Anna-Maria Husa4,
  14. Lisa Ellen Shaw5,
  15. Alexander Lercher1,§,
  16. Pia Gattinger6,
  17. Ricard Torralba-Gombau1,
  18. Doris Trapin7,
  19. Thomas Penz1,
  20. Daniele Barreca1,
  21. Ingrid Fae8,
  22. Sabine Wenda8,
  23. Marianna Traugott9,
  24. Gernot Walder10,
  25. Winfried F. Pickl7,11,
  26. Volker Thiel12,13,
  27. Franz Allerberger14,
  28. Hannes Stockinger3,
  29. Elisabeth Puchhammer-Stöckl2,
  30. Wolfgang Weninger5,
  31. Gottfried Fischer7,
  32. Wolfgang Hoepler9,
  33. Erich Pawelka8,
  34. Alexander Zoufaly8,
  35. Rudolf Valenta3,6,11,15,16,
  36. Christoph Bock1,17,
  37. Wolfgang Paster4,
  38. René Geyeregger4,
  39. Matthias Farlik5,
  40. Florian Halbritter4,
  41. Johannes B. Huppa3,††,
  42. Judith H. Aberle2,†† and
  43. Andreas Bergthaler1,††,*
  1. 1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  2. 2Center for Virology, Medical University of Vienna, Vienna, Austria.
  3. 3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  4. 4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
  5. 5Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  6. 6Department of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.
  7. 7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  8. 8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
  9. 9Department of Medicine 4, Clinic Favoriten, Vienna, Austria.
  10. 10Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  11. 11Karl Landsteiner University of Health Sciences, Krems, Austria.
  12. 12Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
  13. 13Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
  14. 14Austrian Agency for Health and Food Safety (AGES), Vienna, Austria.
  15. 15Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, First Moscow State Medical University Sechenov, Moscow, Russia.
  16. 16NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
  17. 17Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  1. *Correspondence to: A.B. abergthaler{at}cemm.oeaw.ac.at.
  • § Present address: Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA.

  • Equal contributions

  • †† Equal contributions

Altmetric

Article usage

Article usage: March 2021 to April 2021

AbstractFullPdf
Mar 2021694259375183
Apr 2021784871956

Stay Connected to Science Immunology

Navigate This Article