Research ArticleCORONAVIRUS
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
- View ORCID ProfileBenedikt Agerer1,†,
- View ORCID ProfileMaximilian Koblischke2,†,
- View ORCID ProfileVenugopal Gudipati3,†,
- View ORCID ProfileLuis Fernando Montaño-Gutierrez4,
- View ORCID ProfileMark Smyth1,
- View ORCID ProfileAlexandra Popa1,
- View ORCID ProfileJakob-Wendelin Genger1,
- View ORCID ProfileLukas Endler1,
- David M. Florian2,
- Vanessa Mühlgrabner3,
- Marianne Graninger2,
- Stephan W. Aberle2,
- View ORCID ProfileAnna-Maria Husa4,
- View ORCID ProfileLisa Ellen Shaw5,
- View ORCID ProfileAlexander Lercher1,§,
- View ORCID ProfilePia Gattinger6,
- View ORCID ProfileRicard Torralba-Gombau1,
- Doris Trapin7,
- Thomas Penz1,
- View ORCID ProfileDaniele Barreca1,
- View ORCID ProfileIngrid Fae8,
- View ORCID ProfileSabine Wenda8,
- View ORCID ProfileMarianna Traugott9,
- Gernot Walder10,
- Winfried F. Pickl7,11,
- Volker Thiel12,13,
- View ORCID ProfileFranz Allerberger14,
- View ORCID ProfileHannes Stockinger3,
- Elisabeth Puchhammer-Stöckl2,
- Wolfgang Weninger5,
- View ORCID ProfileGottfried Fischer7,
- View ORCID ProfileWolfgang Hoepler9,
- View ORCID ProfileErich Pawelka8,
- Alexander Zoufaly8,
- Rudolf Valenta3,6,11,15,16,
- View ORCID ProfileChristoph Bock1,17,
- View ORCID ProfileWolfgang Paster4,
- View ORCID ProfileRené Geyeregger4,
- View ORCID ProfileMatthias Farlik5,
- View ORCID ProfileFlorian Halbritter4,
- View ORCID ProfileJohannes B. Huppa3,††,
- Judith H. Aberle2,†† and
- View ORCID ProfileAndreas Bergthaler1,††,*
- 1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
- 2Center for Virology, Medical University of Vienna, Vienna, Austria.
- 3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
- 4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
- 5Department of Dermatology, Medical University of Vienna, Vienna, Austria.
- 6Department of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.
- 7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
- 8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
- 9Department of Medicine 4, Clinic Favoriten, Vienna, Austria.
- 10Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
- 11Karl Landsteiner University of Health Sciences, Krems, Austria.
- 12Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
- 13Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
- 14Austrian Agency for Health and Food Safety (AGES), Vienna, Austria.
- 15Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, First Moscow State Medical University Sechenov, Moscow, Russia.
- 16NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
- 17Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
- ↵*Correspondence to: A.B. abergthaler{at}cemm.oeaw.ac.at.
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Science Immunology 04 Mar 2021:
Vol. 6, Issue 57, eabg6461
DOI: 10.1126/sciimmunol.abg6461
Vol. 6, Issue 57, eabg6461
DOI: 10.1126/sciimmunol.abg6461
Benedikt Agerer
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Maximilian Koblischke
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Venugopal Gudipati
3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Luis Fernando Montaño-Gutierrez
4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
Mark Smyth
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Alexandra Popa
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Jakob-Wendelin Genger
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Lukas Endler
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
David M. Florian
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Vanessa Mühlgrabner
3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Marianne Graninger
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Stephan W. Aberle
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Anna-Maria Husa
4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
Lisa Ellen Shaw
5Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Alexander Lercher
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Pia Gattinger
6Department of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.
Ricard Torralba-Gombau
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Doris Trapin
7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Thomas Penz
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Daniele Barreca
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Ingrid Fae
8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Sabine Wenda
8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Marianna Traugott
9Department of Medicine 4, Clinic Favoriten, Vienna, Austria.
Gernot Walder
10Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Winfried F. Pickl
7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
11Karl Landsteiner University of Health Sciences, Krems, Austria.
Volker Thiel
12Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
13Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Franz Allerberger
14Austrian Agency for Health and Food Safety (AGES), Vienna, Austria.
Hannes Stockinger
3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Elisabeth Puchhammer-Stöckl
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Wolfgang Weninger
5Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Gottfried Fischer
7Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Wolfgang Hoepler
9Department of Medicine 4, Clinic Favoriten, Vienna, Austria.
Erich Pawelka
8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Alexander Zoufaly
8Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Rudolf Valenta
3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
6Department of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.
11Karl Landsteiner University of Health Sciences, Krems, Austria.
15Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, First Moscow State Medical University Sechenov, Moscow, Russia.
16NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
Christoph Bock
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
17Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Wolfgang Paster
4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
René Geyeregger
4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
Matthias Farlik
5Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Florian Halbritter
4St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
Johannes B. Huppa
3Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Judith H. Aberle
2Center for Virology, Medical University of Vienna, Vienna, Austria.
Andreas Bergthaler
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
