The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs

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Science Immunology  05 Mar 2021:
Vol. 6, Issue 57, eabh3184
DOI: 10.1126/sciimmunol.abh3184


Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell–dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.

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