April 2021
Vol 6, Issue 58

About The Cover

Cover image expansion

ONLINE COVER Splenic DCs Sticking to the DC-SCRIPT. This month's cover captures the expression of the transcriptional regulator DC-SCRIPT in the mouse spleen using a dtTomato reporter allele. This confocal microscopy image highlights DC-SCRIPT expression in dendritic cells (DCs, red) that are embedded in the T cell zone (CD3, blue), surrounded by B cells (IgM, green) and the marginal zone (CD169, yellow). DC-SCRIPT is also expressed in DCs and macrophages in the red pulp. Zhang et al. found that DC-SCRIPT controls the development and function of type 1 conventional DCs. [CREDIT: WANG CAO AND SHENGBO ZHANG]