Research ArticleAUTOIMMUNITY

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

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Science Immunology  16 Apr 2021:
Vol. 6, Issue 58, eabe0896
DOI: 10.1126/sciimmunol.abe0896

Article Information

vol. 6 no. 58

Published By: 
  • Received July 30, 2020
  • Accepted March 18, 2021
  • .

Author Information

  1. Jia Jia Lim1,,
  2. Claerwen M. Jones1,,
  3. Tiing Jen Loh1,
  4. Yi Tian Ting1,
  5. Pirooz Zareie1,
  6. Khai L. Loh1,
  7. Nathan J. Felix2,
  8. Anish Suri3,,
  9. Murray McKinnon2,
  10. Frederik Stevenaert3,
  11. Ravi K. Sharma4,
  12. Lars Klareskog4,
  13. Vivianne Malmström4,
  14. Daniel G. Baker2,
  15. Anthony W. Purcell1,
  16. Hugh H. Reid1,5,*,§,
  17. Nicole L. La Gruta1,*,§ and
  18. Jamie Rossjohn1,5,6,*,§
  1. 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  2. 2Janssen Research & Development LLC, Horsham, Philadelphia, PA, USA.
  3. 3Janssen Research & Development, Turnhoutseweg 30, BE-2340, Beerse, Belgium.
  4. 4Rheumatology Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 17177 Stockholm, Sweden.
  5. 5Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  6. 6Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
  1. *Corresponding author. Email: hugh.reid{at} (H.H.R.);{at} (N.L.L.G.); jamie.rossjohn{at} (J.R.)
  • These authors contributed equally to this work.

  • Present address: Cue Biopharma, Cambridge, MA, USA.

  • § These authors contributed equally to this work.


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