Research ArticleT CELLS

A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood

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Science Immunology  23 Apr 2021:
Vol. 6, Issue 58, eabf0125
DOI: 10.1126/sciimmunol.abf0125

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Early emergence

γδ T cells are an innate-like subset of T cells that can recognize and respond to microbes. Tan et al. studied the activation and differentiation of γδ T cells to better understand the development and persistence of these cells. They used single-cell RNA sequencing and paired γδTCR analysis from neonatal cord blood or adult peripheral blood and observed a high level of heterogeneity that correlated with TCR usage in immature and differentiated γδ T cell clusters. They detected type 1– and type 3–like Vγ9Vδ2+ T cell subsets with distinct sets of TCR clonotypes, and similar type 3 Vγ9Vδ2+ T cells were found in neonatal cord blood and the early fetal thymus, suggesting that these cells emerge early in fetal development and can persist into adulthood.

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