Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

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Science Immunology  02 Apr 2021:
Vol. 6, Issue 58, eabf4432
DOI: 10.1126/sciimmunol.abf4432

DC-SCRIPT takes center stage

Dendritic cells (DCs) initiate diverse and context-specific adaptive immune responses. Zhang et al. define a role for the transcription factor DC-SCRIPT in the development and function of type 1 conventional DCs (cDC1s) by generating DC-SCRIPT reporter and knockout mouse strains. DC-SCRIPT was required for establishment of the cDC1 gene expression program, as well as cross-presentation of cell-associated antigen and production of IL-12, which are important for stimulating effective type 1 immune responses. The cell type–specific role of DC-SCRIPT was likely due at least in part to its ability to directly control expression of the transcription factor IRF8 in cDC1s, highlighting DC-SCRIPT as a key component of the gene regulatory networks coordinating cDC1 development and function.

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