Research ArticleTUMOR IMMUNOLOGY

Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses

See allHide authors and affiliations

Science Immunology  09 Apr 2021:
Vol. 6, Issue 58, eabg0117
DOI: 10.1126/sciimmunol.abg0117

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Order of immunotherapy matters

Immune checkpoint blockade is clinically successful in various cancer types, yet many treated patients recur; thus, determining effective combination therapies that induce systemic antitumor immunity is crucial. Immune checkpoint blockade combined with local radiation can improve antitumor responses, but it remains unclear how the sequence of these therapies alters efficacy. Here, Wei et al. used mouse tumor models to demonstrate that treatment with anti–PD-1 after stereotactic body radiation therapy (SBRT) elicited superior systemic antitumor immunity, abscopal effects, and protection compared with anti–PD-1 given before SBRT. These data correlated to improved intratumoral CD8+ T cell responses and decreased CD8+ T cell death in local and distant tumors. This work provides preclinical rationale for giving anti–PD-1 after SBRT in patients with cancer.

View Full Text

Stay Connected to Science Immunology