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SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

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Science Immunology  07 Apr 2021:
Vol. 6, Issue 58, eabg0833
DOI: 10.1126/sciimmunol.abg0833

Article Information

vol. 6 no. 58

Published By: 
  • Received December 9, 2020
  • Accepted March 31, 2021
  • .

Author Information

  1. Bingyu Yan1,,
  2. Tilo Freiwald2,3,4,,
  3. Daniel Chauss2,,
  4. Luopin Wang5,,
  5. Erin West3,,
  6. Carmen Mirabelli6,
  7. Charles J Zhang7,
  8. Eva-Maria Nichols8,
  9. Nazish Malik8,
  10. Richard Gregory8,
  11. Marcus Bantscheff8,
  12. Sonja Ghidelli-Disse8,
  13. Martin Kolev8,
  14. Tristan Frum9,
  15. Jason R Spence9,10,
  16. Jonathan Z. Sexton7,9,
  17. Konstantinos D. Alysandratos11,12,
  18. Darrell N. Kotton11,12,
  19. Stefania Pittaluga13,
  20. Jack Bibby3,
  21. Nathalie Niyonzima14,
  22. Matthew R Olson15,
  23. Shahram Kordasti16,17,
  24. Didier Portilla2,18,
  25. Christiane E Wobus6,
  26. Arian Laurence19,
  27. Michail S Lionakis20,
  28. Claudia Kemper3,21,*,,
  29. Behdad Afzali2,*, and
  30. Majid Kazemian1,5,*,
  1. 1Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
  2. 2Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
  3. 3Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
  4. 4Department of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
  5. 5Department of Computer Science, Purdue University, West Lafayette, IN, USA.
  6. 6Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
  7. 7Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  8. 8GlaxoSmithKline, Stevenage, UK.
  9. 9Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, USA.
  10. 10Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
  11. 11Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 1702118, USA.
  12. 12The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
  13. 13Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
  14. 14Center of Molecular Inflammation Research (CEMIR), Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
  15. 15Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
  16. 16CRUK-KHP Centre, Comprehensive Cancer Centre, King’s College London, London, UK.
  17. 17Haematology Department, Guy’s Hospital, London, UK.
  18. 18Division of Nephrology and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, VA, USA.
  19. 19Nuffield Department of Medicine, University of Oxford, UK.
  20. 20Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
  21. 21Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
  1. *Correspondence to: claudia.kemper{at}; behdad.afzali{at}; kazemian{at}
  • These authors contributed equally to this work.

  • These authors contributed equally to this work.


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