Research ArticleMUCOSAL IMMUNOLOGY

IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage

See allHide authors and affiliations

Science Immunology  07 May 2021:
Vol. 6, Issue 59, eabe8856
DOI: 10.1126/sciimmunol.abe8856

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Building back colonic crypts

Restoration of the colonic epithelium after mucosal injury depends on cell renewal initiated by intestinal stem cells (ISCs) and their progeny. Stromal cells near the base of colonic crypts secrete trophic factors for ISCs, but regulation of this process by proinflammatory mediators is not well understood. Cox et al. used mouse models of pathogen- or chemical-induced epithelial damage to investigate the contribution of IL-1 and its receptor (IL-1R1) to epithelial restitution. IL-1 release induced GREM1+ mesenchymal cells to produce R-spondin 3, a Wnt agonist supporting ISC renewal and proliferation. IL-1 also promoted innate lymphoid cell production of IL-22, a cytokine supporting colonocyte proliferation. These findings illustrate the need to consider the desirable regenerative properties of IL-1 when designing therapeutic approaches for chronic inflammatory diseases.

View Full Text

Stay Connected to Science Immunology