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Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

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Science Immunology  13 May 2021:
Vol. 6, Issue 59, eabh2259
DOI: 10.1126/sciimmunol.abh2259

Article Information

vol. 6 no. 59

Published By: 
History: 
  • Received February 24, 2021
  • Accepted May 11, 2021
  • .

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Author Information

  1. Lina Ma1,
  2. Sanjaya K. Sahu1,
  3. Marlene Cano1,
  4. Vasanthan Kuppuswamy2,
  5. Jamal Bajwa1,3,
  6. Ja’Nia McPhatter1,4,
  7. Alexander Pine5,
  8. Matthew L. Meizlish6,
  9. George Goshua5,
  10. C. Hong Chang7,
  11. Hanming Zhang7,
  12. Christina Price8,
  13. Parveen Bahel9,
  14. Henry Rinder9,
  15. Tingting Lei10,
  16. Aaron Day11,
  17. Daniel Reynolds1,
  18. Xiaobo Wu12,
  19. Rebecca Schriefer12,
  20. Adriana M. Rauseo13,
  21. Charles W. Goss14,
  22. Jane A. O’Halloran13,
  23. Rachel M. Presti13,
  24. Alfred H. Kim12,
  25. Andrew E. Gelman10,14,
  26. Charles S. Dela Cruz15,
  27. Alfred I. Lee5,
  28. Philip A. Mudd11,
  29. Hyung J. Chun7,
  30. John P. Atkinson12 and
  31. Hrishikesh S. Kulkarni1,*
  1. 1Division of Pulmonary and Critical Care Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  2. 2Division of Hospital Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  3. 3Marian University, Indianapolis, IN, USA.
  4. 4University of Pittsburgh, Pittsburgh, PA, USA.
  5. 5Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  6. 6Yale School of Medicine, New Haven, CT, USA.
  7. 7Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  8. 8Section of Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  9. 9Yale New Haven Health System, New Haven, CT, USA.
  10. 10Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  11. 11Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  12. 12Division of Rheumatology, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  13. 13Division of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  14. 14Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  15. 15Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  1. *Corresponding author. Email: hkulkarn{at}wustl.edu

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