Research ArticleIMMUNOTHERAPY

All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages

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Science Immunology  11 Jun 2021:
Vol. 6, Issue 60, eaba8426
DOI: 10.1126/sciimmunol.aba8426

Article Information

vol. 6 no. 60

Published By: 
History: 
  • Received January 9, 2020
  • Revision received February 22, 2021
  • Accepted May 10, 2021
  • .

Author Information

  1. Enyu Rao1,2,,
  2. Yuzhu Hou3,4,,
  3. Xiaona Huang3,
  4. Liangliang Wang3,
  5. Jiaai Wang3,
  6. Wenxin Zheng3,
  7. Hengjin Yang1,
  8. Xinshuang Yu5,
  9. Kaiting Yang3,
  10. Jason Bugno6,
  11. Xingchen Ding7,
  12. Everett E. Vokes8,
  13. Yang-Xin Fu9,
  14. Ralph R. Weichselbaum3,* and
  15. Hua Laura Liang3,*,
  1. 1Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  2. 2Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  3. 3Ludwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
  4. 4Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, ShaanXi 710061, China.
  5. 5Department of Oncology, First Affiliated Hospital with Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong 250014, China.
  6. 6Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL, USA.
  7. 7Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250014, China.
  8. 8Department of Medicine, University of Chicago, Chicago, IL, USA.
  9. 9Department of Pathology, University of Texas Southwest Medical Center, Dallas, TX, USA.
  1. *Corresponding author. Email: rrw{at}radonc.uchicago.edu (R.R.W.); hualiang{at}uchicago.edu (H.L.L.)
  • These authors contributed equally to this work.

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