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Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs

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Science Immunology  04 Jun 2021:
Vol. 6, Issue 60, eabd3774
DOI: 10.1126/sciimmunol.abd3774

Article Information

vol. 6 no. 60

Published By: 
  • Received June 17, 2020
  • Revision received January 25, 2021
  • Accepted May 4, 2021
  • .

Author Information

  1. Thorsten Joeris1,2,
  2. Cristina Gomez-Casado2,
  3. Petra Holmkvist2,
  4. Simon J. Tavernier3,4,
  5. Aaron Silva-Sanchez5,
  6. Luisa Klotz6,
  7. Troy D. Randall5,
  8. Allan M. Mowat7,
  9. Knut Kotarsky2,
  10. Bernard Malissen8 and
  11. William W. Agace1,2,*
  1. 1Mucosal Immunology Group, Department of Health Technology, Technical University of Denmark, Kemitorvet, Kgs. Lyngby 2800, Denmark, Denmark.
  2. 2Immunology Section, Lund University, Lund 221 84, Sweden.
  3. 3Primary Immune Deficiency Research Laboratory, Department of Internal Diseases and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent 9000, Belgium.
  4. 4VIB-UGent Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, 9000 Ghent, Belgium.
  5. 5Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  6. 6University Hospital Münster, Department of Neurology with Institute of Translational Neurology, Münster 48149, Germany.
  7. 7Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland.
  8. 8Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, INSERM, CNRS, Marseille, France.
  1. *Corresponding author. Email: william.agace{at}


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