Research ArticleANTIVIRAL IMMUNITY

Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity

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Science Immunology  11 Jun 2021:
Vol. 6, Issue 60, eabi4710
DOI: 10.1126/sciimmunol.abi4710

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The right place at the right time

Protective humoral immunity against viral infections requires an effective type 1 immune response by germinal center (GC) T and B cells, a hallmark of which is expression of the transcription factor T-bet. Mendoza et al. examined the coordinated activity of distinct T-bet–expressing lymphocyte populations during influenza infection in mice, demonstrating that CXCR3-mediated localization of T-bet+ TH1 cells to the T-B boundary opposite T-bet+ B cells is required for GC B cell class switching to antiviral IgG2c. Conversely, T-bet+ T follicular helper cells controlled the magnitude of the GC B cell response but were dispensable for IgG2c class switching. These results demonstrate that the activity of T-bet+ T and B cells are spatiotemporally coordinated to control distinct features of the humoral response to viral infection.

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