Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

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Science Immunology  02 Jul 2021:
Vol. 6, Issue 61, eabi7083
DOI: 10.1126/sciimmunol.abi7083

Article Information

vol. 6 no. 61

Published By: 
  • Received March 25, 2021
  • Accepted June 3, 2021
  • .

Author Information

  1. Marie Siwicki1,
  2. Nicolas A. Gort-Freitas2,
  3. Marius Messemaker1,
  4. Ruben Bill1,
  5. Jeremy Gungabeesoon1,
  6. Camilla Engblom1,
  7. Rapolas Zilionis2,3,
  8. Christopher Garris1,
  9. Genevieve M. Gerhard1,
  10. Anna Kohl1,
  11. Yunkang Lin1,
  12. Angela E. Zou1,
  13. Chiara Cianciaruso1,4,
  14. Evangelia Bolli1,4,
  15. Christina Pfirschke1,
  16. Yi-Jang Lin1,
  17. Cecile Piot1,
  18. John E. Mindur1,
  19. Nilesh Talele5,
  20. Rainer H. Kohler1,
  21. Yoshiko Iwamoto1,
  22. Mari Mino-Kenudson6,
  23. Sara I. Pai7,
  24. Claudio deVito4,8,
  25. Thibaud Koessler9,10,11,
  26. Doron Merkler4,8,
  27. Alexander Coukos12,
  28. Alexandre Wicky12,
  29. Montserrat Fraga13,14,
  30. Christine Sempoux15,
  31. Rakesh K. Jain5,
  32. Pierre-Yves Dietrich9,10,11,
  33. Olivier Michielin12,
  34. Ralph Weissleder1,2,
  35. Allon M. Klein2 and
  36. Mikael J. Pittet1,4,9,10,11,*
  1. 1Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
  2. 2Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  3. 3Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
  4. 4Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
  5. 5Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  6. 6Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  7. 7Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  8. 8Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.
  9. 9Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.
  10. 10Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland.
  11. 11Swiss Cancer Center Leman (SCCL), Lausanne and Geneva, Switzerland.
  12. 12Precision Oncology Center, Department of Oncology, Lausanne University Hospital CHUV, Lausanne, Switzerland.
  13. 13Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
  14. 14Service of Gastroenterology and Hepatology, Lausanne University Hospital, Lausanne, Switzerland.
  15. 15Institute of Pathology, University Hospital and University of Lausanne, Lausanne, Switzerland.
  1. *Corresponding author. Email: mikael.pittet{at}


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