Research ArticleASTHMA

In vivo reprogramming of pathogenic lung TNFR2+ cDC2s by IFNβ inhibits HDM-induced asthma

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Science Immunology  09 Jul 2021:
Vol. 6, Issue 61, eabi8472
DOI: 10.1126/sciimmunol.abi8472

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IFNβ is a breath of fresh air

Allergen-induced asthma affects millions of people; thus, treatments to alleviate symptoms are needed. Lung inflammation from allergen-induced asthma, specifically house dust mite (HDM) mouse models, is induced by inflammatory lung TNFR2+ conventional DC2s (cDC2). Here, Mansouri et al. demonstrated that treating mice with intranasal IFNβ, an important factor for maintaining immune tolerance in the lung, alleviated asthma symptoms in HDM mouse models by making TNFR2+ cDC2s more tolerogenic. The IFNβ-induced TNFR2+ cDC2s led to the generation of anti-inflammatory Tregs in an ERK- and fatty acid oxidation–dependent manner. These results could be replicated with human lung TNFR2+ cDC2s. Thus, inhaled IFNβ may represent a potential therapy to alleviate allergen-induced asthma in people.

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