Science Immunology

Supplementary Materials

Supplementary Material for:

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Thomas Condamine, George A. Dominguez, Je-In Youn, Andrew V. Kossenkov, Sridevi Mony, Kevin Alicea-Torres, Evgenii Tcyganov, Ayumi Hashimoto, Yulia Nefedova, Cindy Lin, Simona Partlova, Alfred Garfall, Dan T. Vogl, Xiaowei Xu, Stella C. Knight, George Malietzis, Gui Han Lee, Evgeniy Eruslanov, Steven M. Albelda, Xianwei Wang, Jawahar L. Mehta, Meenakshi Bewtra, Anil Rustgi, Neil Hockstein, Robert Witt, Gregory Masters, Brian Nam, Denis Smirnov, Manuel A. Sepulveda, Dmitry I. Gabrilovich*

*Corresponding author. Email: dgabrilovich{at}

Published 5 August 2016, Sci. Immunol. 1, aaf8943 (2016)
DOI: 10.1126/sciimmunol.aaf8943

This PDF file includes:

  • Fig. S1. Gene expression differences between PMN-MDSCs and PMNs cells from cancer patients and healthy donors.
  • Fig. S2. CD16 and LOX-1 staining in PMN.
  • Fig. S3. Siglec-8 staining of CD15+ PMN.
  • Fig. S4. LOX1 staining of healthy donor neutrophils.
  • Fig. S5. List of genes and their relative expression targeted by 93 microarray probes shown to be highly differentially expressed (FDR < 5%, fold > 2) for both LOX-1+/LOX-1− and PMN-MDSC/PMN comparisons.
  • Fig. S6. LOX-1 antibody does not induce immunosuppressive activity of PMN.
  • Fig. S7. LOX-1 expression in mouse PMN-MDSC.
  • Fig. S8. LOX-1 expression is not associated with mouse PMN-MDSC.
  • Table S1. Canonical pathways identified by IPA among genes significantly differentially expressed between PMN-MDSC and PMN cells.

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Other Supplementary Material for this manuscript includes the following:

  • Source data (Excel)

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