Science Immunology

Supplementary Materials

Supplementary Material for:

IL-1β is an innate immune sensor of microbial proteolysis

Christopher N. LaRock,* Jordan Todd, Doris L. LaRock, Joshua Olson, Anthony J. O'Donoghue, Avril A. B. Robertson, Matthew A. Cooper, Hal M. Hoffman, Victor Nizet*

*Corresponding author. Email: clarock{at}ucsd.edu (C.N.L.); vnizet{at}ucsd.edu (V.N.)

Published 19 August 2016, Sci. Immunol. 1, eaah3539 (2016)
DOI: 10.1126/sciimmunol.aah3539

This PDF file includes:

  • Methods
  • Fig. S1. Examination of inflammasome dependence of IL-1β activation.
  • Fig. S2. Potentiation of GAS infection by NLRP3 inhibition.
  • Fig. S3. SpeB colocalization with IL-1β.
  • Fig. S4. SpeB does not activate caspase-8 or caspase-8–like proteolysis.
  • Fig. S5. SpeB induces cell death and antagonizes canonical inflammasome activation.
  • Fig. S6. Kinetics of activation by caspase-1 or SpeB during infection.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Source data statistics for all figures.
  • Table S2 (Microsoft Excel format). Report IDs positive for indicated drug-adverse reaction.
  • Table S3 (Microsoft Excel format). List of suspected duplicate drug adverse reports.

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