Science Immunology

Supplementary Materials

Supplementary Material for:

Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation

E. Ashley Moseman, Tuoqi Wu, Juan Carlos de la Torre, Pamela L. Schwartzberg, Dorian B. McGavern*

*Corresponding author. Email: mcgavernd{at}

Published 21 October 2016, Sci. Immunol. 1, eaah3565 (2016)
DOI: 10.1126/sciimmunol.aah3565

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Effects of IFNAR blockade and virus strain or titer on LCMV-specific B cells.
  • Fig. S2. CTL engagement of antiviral B cells and control LCMV-iCre–infected Confetti mice.
  • Legends for movies S1 to S6
  • References (6672)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). LCMV-specific B cells thrive upon late transfer into infected hosts.
  • Movie S2 (.mov format). IFNAR blockade prevents deletion of LCMV-specific B cells.
  • Movie S3 (.mov format). LCMV-specific CTLs flux calcium upon contact with LCMV-specific B cells.
  • Movie S4 (.mov format). Antiviral CTLs productively engage LCMV-specific B cells.
  • Movie S5 (.mov format). LCMV-specific B cells are killed in vivo.
  • Movie S6 (.mov format). LCMV-infected B cells contribute to clonal GCs in the absence of functional CTLs.
  • Table S1 (Microsoft excel format). Excel file containing tabulated data for Figs. 1 to 7 and fig. S1.

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