Science Immunology

Supplementary Materials

Supplementary Material for:

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

S. Alice Long, Jerill Thorpe, Hannah A. DeBerg, Vivian Gersuk, James A. Eddy, Kristina M. Harris, Mario Ehlers, Kevan C. Herold, Gerald T. Nepom, Peter S. Linsley*

*Corresponding author. Email: plinsley{at}benaroyaresearch.org

Published 18 November 2016, Sci. Immunol. 1, eaai7793 (2016)
DOI: 10.1126/sciimmunol.aai7793

This PDF file includes:

  • Methods
  • Fig. S1. Schematic representation of the AbATE trial of teplizumab in newly diagnosed T1D.
  • Fig. S2. Identifying biological themes enriched in top C-peptide genes.
  • Fig. S3. An NK/T cell, EOMES-associated gene signature was detected in whole blood of teplizumab R patients.
  • Fig. S4. GSEA shows positive correlation between EOMES.mod and other overlapping modules with the R phenotype.
  • Fig. S5. Correlation of EOMES expression with lymphocyte subset levels.
  • Fig. S6. Diagram of flow cytometric single-cell analysis of EOMES-associated proteins.
  • Fig. S7. Representative gating for univariate expression analysis by flow cytometry on T and NK cell subsets.
  • Fig. S8. Representative gating for coexpression longitudinal analysis by flow cytometry.
  • References (4255)

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Correction: Patient IDs in Table S1 were substituted with masked patient IDs.

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Numbers and characteristics of samples used in this study.
  • Table S2 (Microsoft Excel format). EOMES-correlated genes.
  • Table S3 (Microsoft Excel format). Flow cytometry panels.
  • Table S4 (Microsoft Excel format). TCR rearrangements in DH cells versus DL cells.

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