Science Immunology

Supplementary Materials

Supplementary Material for:

Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque

Edward Smith, Sara Croca, Kirsty E. Waddington, Reecha Sofat, Maura Griffin, Andrew Nicolaides, David A. Isenberg, Ines Pineda Torra, Anisur Rahman, Elizabeth C. Jury*

*Corresponding author. Email: e.jury{at}ucl.ac.uk

Published 2 December 2016, Sci. Immunol. 1, eaah4081 (2016)
DOI: 10.1126/sciimmunol.aah4081

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Analysis of iNKT cell phenotype in SLE patients and HCs.
  • Fig. S2. iNKT cells from SLE-P patients had an activated phenotype compared with SLE-NP patients and HCs.
  • Fig. S3. Serum cytokine and metabolite expression levels in SLE patients with and without plaque.
  • Fig. S4. Hierarchical clustering of metabolites with most significant differences between SLE-NP and SLE-P patients.
  • Fig. S5. Monocyte/macrophage phenotype in SLE-P and SLE-NP patients and HCs.
  • Fig. S6. iNKT cell frequency and IL-4 production correlate with plaque stability measured by GSM.
  • Fig. S7. Comparison of serum lipid profiles in SLE-P and SLE-CV patients.
  • Table S1. SLE patient and HC characteristics.
  • Table S2. Plasma cytokine levels measured by proteomic analysis in SLE-P patients compared with those without plaque.
  • Table S3. Serum metabolites significantly altered in SLE-P patients compared with those without plaque.
  • Table S4. SLE patient serum lipids and biomarkers.
  • Table S5. Correlation of serum metabolites with iNKT cell frequency and IL-4 production in SLE-P and SLE-NP patients.
  • Table S6. SLE-CV patient clinical characteristics.
  • References (5256)

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