Science Immunology

Supplementary Materials

Supplementary Material for:

Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response

Birgit Lehmann, Markus Biburger, Christin Br?ckner, Andrea Ipsen-Escobedo, Sina Gordan, Christian Lehmann, David Voehringer, Thomas Winkler, Niels Schaft, Diana Dudziak, Horia Sirbu, Georg F. Weber, Falk Nimmerjahn*

*Corresponding author. Email: falk.nimmerjahn{at}

Published 6 January 2017, Sci. Immunol. 1, eaah6413 (2017)
DOI: 10.1126/sciimmunol.aah6413

This PDF file includes:

  • Fig. S1. Leukocyte subsets in murine and human lung tumor tissue.
  • Fig. S2. FcγRIV-expressing immune cell subsets in subcutaneous tumors.
  • Fig. S3. FcγRIV expression on blood leukocytes after cytokine stimulation.
  • Fig. S4. Leukocyte distribution in CCR2- and CSF2-deficient mice.
  • Fig. S5. Cytokines in B16F10 cell culture supernatant and serum of tumor-bearing mice.
  • Fig. S6. Role of mast cells and basophils in antibody-dependent tumor immunotherapy.
  • Fig. S7. Role of the CCL2-CCR2 axis in antibody-mediated protection against EL4 subcutaneous tumors.
  • Fig. S8. Impact of lung tissue–resident cells on therapeutic antibody activity.
  • Fig. S9. Isotype control staining.
  • Table S1. Primary source data.

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