Science Immunology

Supplementary Materials

Supplementary Material for:

Plasmodium products persist in the bone marrow and promote chronic bone loss

Michelle S. J. Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M. Lelliott, Sawako Itagaki, Toshihiro Horii, Jing-wen Lin, Shahid M. Khan, Etsushi Kuroda, Shizuo Akira, Ken J. Ishii, Cevayir Coban*

*Corresponding author. Email: ccoban{at}

Published 2 June 2017, Sci. Immunol. 2, eaam8093 (2017)
DOI: 10.1126/sciimmunol.eaam8093

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Bone loss in P. chabaudi infection and suppression of bone growth in PyNL-infected young mice.
  • Fig. S2. Gene expression of inflammatory cytokines in the bone.
  • Fig. S3. PyNL crude extract elicits inflammation in OCPs, OBPs, and OBs.
  • Fig. S4. Comparison between Myd88+/− and Myd88−/− mice.
  • Fig. S5. Chloroquine does not rescue Plasmodium-infected mice from bone loss.
  • Fig. S6. Serum cytokines of Rag2−/− mice infected with WT PbA and mutant PbAΔpm4Δbp2.
  • Fig. S7. Bone marrow infection of PbA-infected and mutant Δpm4Δbp2-infected mice.
  • Table S1. Possible association between malaria infection and child growth.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 Excel file containing source data in tabular format for all figures.

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