Science Immunology

Supplementary Materials

Supplementary Material for:

Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions

Khalid Bin Dhuban, Eva d'Hennezel, Yasuhiro Nagai, Yan Xiao, Steven Shao, Roman Istomine, Fernando Alvarez, Moshe Ben-Shoshan, Hans Ochs, Bruce Mazer, Bin Li, Chiyoko Sekine, Alan Berezov, Wayne Hancock, Troy R. Torgerson, Mark I. Greene, Ciriaco A. Piccirillo*

*Corresponding author. Email: ciro.piccirillo{at}mcgill.ca

Published 16 June 2017, Sci. Immunol. 2, eaai9297 (2017)
DOI: 10.1126/sciimmunol.aai9297

This PDF file includes:

  • Fig. S1. Reduced expression of FOXP3A384T alters its ability to induce CD25 expression.
  • Fig. S2. Cytokine repression is maintained by FOXP3A384T.
  • Fig. S3. Unmodified blots from Fig. 4.
  • Fig. S4. Model for the mechanism of action of TIP60 modifiers in the TIP60- p300-FOXP3 interaction in Treg cells.
  • Fig. S5. Enhanced FOXP3-TIP60 interaction in response to SGF003 treatment in Jurkat cell line.
  • Fig. S6. Unmodified blots from Fig. 5 (A and B).
  • Fig. S7. Unmodified blots from Fig. 5C.
  • Fig. S8. Enhancement of TIP60-FOXP3 interaction by B7A.
  • Fig. S9. Improvement of Treg suppressive capacity by B7A-mediated enhancement of TIP6-FOXP3 interaction.
  • Fig. S10. TH17 differentiation is not altered by SGF003 treatment.
  • Fig. S11. Treatment of CIA with B7A.
  • Table S1. Differentially expressed genes in FOXP3A384T-transduced cells.
  • Table S2. SGF treatment improves the expression of several FOXP3-regulated genes.

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